Genetic Susceptibility Research Core
Overview
Genetic susceptibility refers to how variations in a person's genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (e.g., diet and smoking). In this Core, researchers focus on molecular epidemiology, DNA repair, and gene-environment interaction to identify factors which affect the incidence of environmental diseases. Using genetic markers, researchers work to identify genes that influence the outcomes of exposure to environmental toxins. These genes can then be used to identify persons who are highly susceptible to environmental hazards. Susceptibility may be especially important with chronic low-level exposures (such as may occur with environmental radiation or air / water pollutants). Health effects research in this Core focuses on cancers with known or suspected environmental causes, birth defects, heart disease, and respiratory diseases such as asthma.
Objectives
The Genetic Susceptibility Research Core has the following objectives:
- to support and expand collaborative research in genetic susceptibility utilizing state-of-the-art laboratory methods and rigorously designed epidemiologic approaches;
- to integrate, on a regular basis, researchers in mechanisms of DNA damage and repair and epidemiologists involved in field studies of gene/environment interactions in carcinogenesis;
- to promote the integration of molecular genetics into areas of reproductive, pediatric, pulmonary and cardiovascular research;
- to foster dialogue regarding policy implications of genetic-testing technology and results of genetic research; and
- to stimulate new collaborations through pilot studies.
Genetic Susceptibility Research Core Accomplishments - 2006
